Medical Director, Global Medical Affairs, ATTR

The Medical Director, Global Medical Affairs, ATTR serves as a global medical and scientific leader for ATTR, providing strategic expertise across Global Medical Affairs.

This highly visible role blends scientific leadership, global external engagement, and cross-functional influence to advance evidence generation, medical education, and innovative implementation-science initiatives that support optimal patient identification, diagnosis, and management worldwide.

Key Responsibilities

External Scientific Leadership & Engagement

• Serve as a global medical expert for ATTR engaging international KOLs and expert centers to advance scientific exchange and collaboration.
• Lead and support global advisory boards and a major global advisory summit, including agenda development, faculty engagement, and synthesis of actionable insights.
• Drive scientific discussions focused on disease awareness, diagnostic pathways, and treatment optimization.
• Represent Global Medical Affairs at major international congresses, symposia, and external scientific forums.
• Build and sustain strong, trust-based relationships with global thought leaders to inform strategy and identify collaborative opportunities.
• Generate, synthesize, and disseminate global medical insights to inform strategic decision-making and regional execution.

Global Medical Strategy, Evidence & Internal Leadership

• Support development and execution of the integrated global medical affairs strategy for ATTR in alignment with senior medical leadership.
• Lead and advance implementation-science initiatives and screening and diagnostic projects.
• Provide global medical leadership for scientific communications and publications, serving as a representative on cross-functional strategy teams.
• Contribute to publication planning, data interpretation, and scientific dissemination across global and regional teams.
• Partner closely with regional medical teams to ensure consistent scientific narratives, coordinated rollout of initiatives, and bidirectional insight flow.
• Collaborate cross-functionally with Clinical Development, VESt, Regulatory, Commercial, and other Medical Affairs partners to support integrated evidence generation.
• Monitor competitor activity and evolving scientific landscape to inform global medical strategy.
• Uphold the highest standards of scientific integrity, compliance, and ethical governance across all medical activities.

Key Deliverables & Success Indicators

• Successful execution and measurable impact of global advisory boards.
• Actionable global medical insights that inform strategy and regional plans.
• Advancement of implementation-science and AI-enabled screening initiatives with real-world impact.
• High-quality, timely scientific communications and publications aligned with strategic priorities.
• Strong, productive relationships with global KOLs and regional medical teams.
• Consistent global scientific narratives and effective dissemination of data and insights.
• Full adherence to medical governance, compliance, and quality standards.

This a hybrid role with two days a week onsite presence based in our Cambridge, MA or Philadelphia, PA office.

In addition, this is one of two available positions: one supporting Nucresiran and one supporting Vutrisiran.

Qualifications

• MD, PharmD, or PhD required.
• 5-7+ years of experience in Clinical Research and/or Medical Affairs within the pharmaceutical or biotechnology industry.
• Experience in cardiovascular, renal, metabolic or ATTR strongly preferred.
• Demonstrated success engaging global KOLs and leading advisory boards and scientific initiatives.
• Strong cross-functional leadership skills with ability to influence in a matrixed global environment.
• Excellent communication, scientific storytelling, and strategic execution capabilities.
• Ability to operate effectively in a fast-paced, high-accountability global role.

U.S. Pay Range

$238,800.00 - $323,000.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.