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Senior Portfolio Delivery Manager- Precision Oncology

Exact Sciences
paid time off
United States, Wisconsin, Madison
Feb 09, 2026

Help us change lives

At Exact Sciences, we're helpingchange how the world prevents, detects and guides treatment for cancer. We give patients and clinicians the clarity needed to make confident decisions when they matter most. Join our team to find a purpose-driven career, an inclusive culture, and robust benefits to support your life while you're working to help others.

Position Overview

The Sr. PO Portfolio Delivery Manager plays a pivotal role in advancing the priorities of the Precision Oncology (PO) portfolio of products by driving the successful execution of strategic initiatives outlined in the PO annual operating and mid-range plans. This role oversees large, high risk, and high-visibility initiatives that are critical to the organization, often involving complex challenges and wide-ranging impact.

A hands-on role, the Sr. PO Portfolio Delivery Manager works closely with all levels of the organization to ensure alignment and collaboration. Serving as a thought leader, the Sr. PO Portfolio Delivery Manager fosters cooperation across functions and engages with leadership to support key initiatives. This position ensures seamless integration and communication across multiple direct and related initiatives, partnering with leadership to ensure successful outcomes.

The "how" is just as important as the "what." The Sr. PO Portfolio Delivery Manager is skilled at bringing cross-functional teams together to drive meaningful results. With a focus on mutual respect and inclusivity, they create a sense of trust, creativity, innovation, authenticity, and shared ownership across the organization.

This is a hybrid role based in our Madison, WI office location.

Essential Duties

Include, but are not limited to, the following:

  • Collaborate with internal cross functional teams and senior leadership to develop strategies, goals, and initiatives to support the current and anticipated needs of the PO portfolio of products.
  • Develop and present status updates to multiple audiences (initiative teams to leadership) that effectively convey status, obstacles and solutions, opportunities.
  • Facilitate defining success metrics for a given initiative (OKRs and KPIs); manage the tracking and reporting of those metrics; support the team in promoting their accomplishments.
  • Maintain program metrics around initiative goals and communicate progress to key stakeholders.
  • Drive positive organizational change management processes via planning, communications, and relationship management.
  • Facilitate, organize, and monitor inter-connected initiatives, including coordination of cross-initiative activities.
  • Manage escalation process when critical risks arise and manage dependencies across initiatives accordingly to minimize impact to the key deliverables.
  • Assess organizational impacts for initiatives or programs and develop the appropriate tactics to best fit each audience with the right level of communications, engagement, training, and support.
  • Ability to effectively collaborate as a part of a team and operate independently across initiatives based on complexity and needs.
  • Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork.
  • Support and comply with the company's Quality Management System policies and procedures.
  • Maintain regular and reliable attendance.
  • Act with an inclusion mindset and model these behaviors for the organization.
  • Ability and means to travel between local Exact Sciences locations.
  • Ability to travel 10% of working time away from work location, may include overnight/weekend travel.

Minimum Qualifications

  • Bachelor's Degree in Business, Science, Engineering, or other relevant field as outlined in the essential duties.
  • 4+ years of portfolio delivery experience with increasing scope and responsibility in diagnostic, biopharma, or medical device fields.
  • Experience directly and/or indirectly leading people with demonstrated ability to communicate clear expectations, motivate and inspire others, and successfully achieve goals through a team.
  • Strong communication, presentation, interpersonal, and analytical skills.
  • Demonstrated ability to lead large cross-functional teams.
  • Experience in relationship building, motivation, and curiosity to bring together different personalities for creative thinking and collaborative solutioning.
  • Strong leadership skills, including the ability to influence multiple stakeholders and leaders without direct authority.
  • Advanced problem-solving, organizational, and analytical skills with the ability to evolve operational models.
  • Demonstrated ability to perform the essential duties of the position with or without accommodation.
  • Applicants must be currently authorized to work in country where work will be performed on a full or part-time basis. We are unable to sponsor or take over sponsorship of employment visas at this time.

Preferred Qualifications

  • Lean Six Sigma Green Belt (or higher) certification.
  • Master's degree in Business Administration, Scientific discipline, or field related to the essential duties of the job
  • 7+ years of experience working in a team setting in healthcare, biopharma, medical device, or technology fields with experience in two or more of the following: strategic planning, business development, portfolio management, product development, product lifecycle management, operations management, and/or commercialization including sales or marketing.
  • 5+ years of experience working in U.S. and global regulated environments.
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Salary Range:

$91,000.00 - $155,000.00

The annual base salary shown is for this position located in US - WI - Madison on a full-time basis. In addition, this position is bonus eligible.

Exact Sciences is proud to offer an employee experience that includes paid time off (including days for vacation, holidays, volunteering, and personal time), paid leave for parents and caregivers, a retirement savings plan, wellness support, and health benefits including medical, prescription drug, dental, and vision coverage. Learn more about our benefits.

Our success relies on the experiences and perspectives of a diverse team, and Exact Sciences fosters a culture where all employees can develop personally and professionally with a sense of respect and belonging. If you require an accommodation, please contact us here.

Not ready to apply? Join our Talent Community to stay updated on the latest news and opportunities at Exact Sciences.

We are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to disability, protected veteran status, and any other status protected by applicable local, state, or federal law.

To view the Right to Work, E-Verify Employer, and Pay Transparency notices and Federal, Federal Contractor, and State employment law posters, visit our compliance hub. The documents summarize important details of the law and provide key points that you have a right to know.

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